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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS13C All Species: 26.06
Human Site: T181 Identified Species: 71.67
UniProt: Q709C8 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q709C8 NP_001018098.1 3753 422390 T181 P K E A K K D T F V E K L A T
Chimpanzee Pan troglodytes XP_510458 3836 431033 T263 P K E A K K D T F V E K L A T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_851912 3629 408076 T181 P K E A K K D T F L E K L A T
Cat Felis silvestris
Mouse Mus musculus Q8BX70 3748 420070 T181 P K E A K K D T F L E K L A T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511058 3801 426177 T215 P K E A K K D T F L E K L A T
Chicken Gallus gallus XP_001233000 3758 422392 T181 T K E E K K D T F L E K L A T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922767 3699 412330 T180 P Q E E K K D T F A E K L A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001192977 2470 271032
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q07878 3144 357831
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.9 N.A. 87 N.A. 86.4 N.A. N.A. 77.2 68.7 N.A. 59.6 N.A. N.A. N.A. N.A. 24.1
Protein Similarity: 100 97.4 N.A. 92 N.A. 93.3 N.A. N.A. 87.6 82.9 N.A. 76.8 N.A. N.A. N.A. N.A. 41
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 N.A. N.A. 93.3 80 N.A. 80 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 N.A. 100 N.A. 100 N.A. N.A. 100 86.6 N.A. 86.6 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 39.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 56 0 0 0 0 0 12 0 0 0 78 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 78 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 78 23 0 0 0 0 0 0 78 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 78 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 67 0 0 78 78 0 0 0 0 0 78 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 45 0 0 78 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 12 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 12 0 0 0 0 0 0 78 0 0 0 0 0 0 78 % T
% Val: 0 0 0 0 0 0 0 0 0 23 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _